1. Epigenetics TGF-beta/Smad
  2. PKC
  3. Bisindolylmaleimide XI hydrochloride

Bisindolylmaleimide XI hydrochloride  (Synonyms: Ro 32-0432; Ro 31-8830 hydrochloride)

目录号: HY-117610A 纯度: ≥98.0%
COA 产品使用指南

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) 是一种有效、选择性和具有口服活性的 PKC 抑制剂,对 PKCαPKCβIPKCβIIPKCγIC50 分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM。

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Bisindolylmaleimide XI hydrochloride Chemical Structure

Bisindolylmaleimide XI hydrochloride Chemical Structure

CAS No. : 145333-02-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively[1][2].

IC50 & Target[1]

PKC-α

9 nM (IC50)

PKC-βI

28 nM (IC50)

PKC-βII

31 nM (IC50)

PKC-γ

37 nM (IC50)

PKC-ε

108 nM (IC50)

体外研究
(In Vitro)

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride[2].
PKC inhibition with Bisindolylmaleimide XI hydrochloride (Ro 32-0432; 1 μM) decreases the proportion of apoptotic cells (-21%) in retinal progenitor cells (RPCs)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

489.01

Formula

C28H29ClN4O2

CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

参考文献

Bisindolylmaleimide XI hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bisindolylmaleimide XI hydrochloride
目录号:
HY-117610A
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