2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. BLM-IN-2

BLM-IN-2 是一种布鲁姆氏综合征蛋白 (BLM) 抑制剂，其 IC50 值为 0.8 μM。BLM-IN-2 能有效抑制结直肠癌细胞的增殖、侵袭、细胞周期阻滞和凋亡。BLM-IN-2 可用于结直肠癌 (CRC) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BLM-IN-2 Chemical Structure

BLM-IN-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

BLM-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC)[1].

IC50 & Target

IC50: 0.8 μM (BLM)[1]
体外研究
(In Vitro)

BLM-IN-2 (0-20 μM) 对 BLM 有良好的抑制作用，解旋和结合 DNA 的 IC50 值分别为 0.8 μM 和 2.3 μM[1]。
BLM-IN-2 对 CRC 细胞表现出强大的 BLM 依赖性细胞毒性，但对正常细胞表现出弱毒性[1]。
BLM-IN-2（3 μM；48 h）破坏 HRR 水平，同时抑制位于 DSB 位点的 BLM，并触发 CRC 细胞中的 DNA 损伤[1]。
BLM-IN-2 (0-5 μM; 48 h) 有效抑制 CRC 细胞的增殖和侵袭，以及细胞周期停滞和细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BLM-IN-2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT116 cells; HCT116, SW480 and RKO cells
Concentration: 0-5 μM; 0.5, 1, 2 μM
Incubation Time: 48 h; 10 days
Result: Induced proliferation arrest.
Completely inhibited the growth of cancer cells at the concentration around 2 μM, had a good anti-CRC activity.

Apoptosis Analysis[1]

Cell Line: HCT116, SW480 and RKO cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced apoptosis and necrosis in HCT116, SW480 and RKO.

Cell Cycle Analysis[1]

Cell Line: HCT116, SW480 and RKO cells
Concentration: 4 μM
Incubation Time: 48 h
Result: Changed the cell proportion of the S or G2/M phase in CRC cells, arrested the cell cycle at the S phase in HCT116 and SW480 and arrested the cell cycle of HCT116, SW480 and RKO at the G2/M phase.

Cell Invasion Assay[1]

Cell Line: HCT116 cells
Concentration: 0.25, 0.5, 1, 2, 4 μM
Incubation Time: 48 h
Result: Obviously decreased the invasion in HCT116 cells with an IC50 value of 1.0 μM and had inhibitory on CRC invasion.
分子量

605.58

Formula

C33H38BrFN4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BLM-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLM-IN-2DNA/RNA SynthesisApoptosishomologous recombination repair (HRR)double-strand breaks (DSB)Bloom's Syndrome Protein (BLM)colorectal cancer (CRC)Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
BLM-IN-2
目录号：
HY-151939
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z