Boc-Phe-Leu-Phe-Leu-Phe  (Synonyms: L-BOC2)

Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel^[1][2][3].

Boc-Phe-Leu-Phe-Leu-Phe (0-50 μg/mL) 抑制 PDR 玻璃体诱导的 HUVEC 球体在三维纤维蛋白凝胶中的出芽^[1]。
Boc-Phe-Leu-Phe-Leu-Phe (0-120 μM，24 小时) 以剂量依赖方式抑制 VEGF 介导的 HUVEC 球体出芽^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

785.97

C₄₄H₅₉N₅O₈

73572-58-4

固体

White to off-white

{Boc}-Phe-Leu-Phe-Leu-Phe

{Boc}-FLFLF

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Rezzola S, et al. Inflammation and N-formyl peptide receptors mediate the angiogenic activity of human vitreous humour in proliferative diabetic retinopathy. Diabetologia. 2017 Apr;60(4):719-728.  [Content Brief]

  [2]. Nawaz MI, et al. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Angiogenesis. 2020 Aug;23(3):357-369.  [Content Brief]

  [3]. Lefer AM, Roth DM, Kugler JL, Smith JB. Modulation of receptor mediated leukotriene release in the perfused heart. Gen Pharmacol. 1986;17(4):437-40.  [Content Brief]