2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK Apoptosis
  3. Carbonic Anhydrase c-Met/HGFR Apoptosis
  4. CAIX/XII-IN-16

CAIX/XII-IN-16 (Compound 5d) 是一种选择性的 CA IX/XII 和 c-Met 抑制剂，其对于 hCA IX、hCA XII 和 CA I 的 Ki 值为 10.6、31.8 和 2361 nM，对 c-Met 的 IC50 值为 0.49 μM。CAIX/XII-IN-16 在低氧条件下对结肠癌细胞表现出显著增强的细胞毒性。CAIX/XII-IN-16 引起细胞周期阻滞，并诱导了细胞凋亡 (apoptosis)。CAIX/XII-IN-16 显著增强 Oxaliplatin (HY-17371) 和 5-Fluorouracil (HY-90006) 的疗效。CAIX/XII-IN-16 可用于低氧相关化疗耐药性研究。

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CAIX/XII-IN-16

CAIX/XII-IN-16 Chemical Structure

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CAIX/XII-IN-16 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAIX/XII-IN-16 (Compound 5d) is a selective inhibitor of CA IX/XII and c-Met. CAIX/XII-IN-16‘s Ki values for hCA IX, hCA XII and CA I are 10.6, 31.8 and 2361 nM respectively, and its IC50 value for c-Met is 0.49 μM. CAIX/XII-IN-16 exhibits significantly enhanced cytotoxicity against colon cancer cells under hypoxic conditions. CAIX/XII-IN-16 causes cell cycle arrest and induces apoptosis (apoptosis). CAIX/XII-IN-16 significantly enhances the efficacy of Oxaliplatin (HY-17371) and 5-Fluorouracil (HY-90006). CAIX/XII-IN-16 can be used for studies on chemotherapy resistance related to hypoxia[1].

IC50 & Target[1]

hCA IX

10.6 nM (Ki)

hCA XII

31.8 nM (Ki)

hCA I

2361 nM (Ki)

c-Met

0.49 μM (IC50)

分子量

439.45

Formula

C19H17N7O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAIX/XII-IN-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/XII-IN-16Carbonic Anhydrasec-Met/HGFRApoptosisCarbonate dehydrataseDual CA IX and c-met inhibitorsColon CancerHypoxiaHIF-1αChemosensitizationDockingInhibitorinhibitorinhibit

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产品名称：
CAIX/XII-IN-16
目录号：
HY-179034
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