1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. CALP3 TFA

CALP3 TFA 是一种类似于 Ca2+ 的肽,是有效的 Ca2+ 通道阻滞剂,可激活 Ca2+ 结合蛋白的 EF 手。CALP3 TFA 可以通过调节钙调蛋白 (CaM),Ca2+ 通道和泵的活性来模拟增加的 [Ca2+]i。CALP3 TFA 具有控制诸如艾滋病或由于缺血引起的神经元丢失等疾病中细胞凋亡的潜力。

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Custom Peptide Synthesis

CALP3 TFA Chemical Structure

CALP3 TFA Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2].

体外研究
(In Vitro)

CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1].
CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50=50.97 μM) in cultured rat neocortical neurons. CALP3 TFA causes dose-dependent inhibition of apoptosis (IC50=33.41 μM)[1].
CALP3 TFA (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells[1].
CALP3 TFA (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells[2].
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

995.10

Formula

C46H69F3N10O11

Sequence Shortening

VKFGVGFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CALP3 TFA
目录号:
HY-P1075A
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