1. Stem Cell/Wnt TGF-beta/Smad
  2. TGF-beta/Smad
  3. Carotuximab

Carotuximab  (Synonyms: TRC105; DE-122)

目录号: HY-P99494 纯度: ≥95.0%
COA

Carotuximab (TRC105) 是一种 IgG1 单克隆抗体,可阻断内皮糖蛋白 (CD105) 及其下游 Smad 信号通路。Carotuximab 具有免疫调节和抗肿瘤作用。

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Carotuximab Chemical Structure

Carotuximab Chemical Structure

CAS No. : 1268714-50-6

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions[1][2].

体外研究
(In Vitro)

Carotuximab (TRC105;300 μg/mL;预处理 1 小时,然后共培养 12 小时) 降低人主动脉内皮细胞中 7-酮胆固醇诱导的内皮糖蛋白 (Eng) 蛋白水平和 pSmad1/5 和 pSmad2/3 信号通路。Carotuximab 介导的 Eng 阻断阻止了 7-酮胆固醇诱导的单核细胞通过内皮单层细胞的粘附和迁移[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human aortic endothelial cells (HAoECs)
Concentration: 300 μg/mL
Incubation Time: Pretreatment 1 h, and then co-cultured for 12 h
Result: Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
体内研究
(In Vivo)

Carotuximab(TRC105;2 mg/kg;i.v;每 3 天一次;持续 8 周)与 Decitabine 一起在急性髓性白血病 (AML) 异种移植物中产生更持久的抗白血病作用,并且还能增强活性氧 (ROS) 活性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells[2]
Dosage: 2 mg/kg
Administration: i.v; every 3 days; for 8 weeks
Result: Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

卡妥昔单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: ≥95.0%

参考文献

Carotuximab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Carotuximab
目录号:
HY-P99494
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