2. Apoptosis Cell Cycle/DNA Damage
  3. CDK Apoptosis
  4. CDK9-IN-24

CDK9-IN-24 (compound 21a) 是一种高选择性 CDK9 抑制剂，对肿瘤生长的显着抑制作用。CDK9-IN-24 有效阻碍细胞增殖，并通过下调 Mcl-1 和 c-Myc 诱导细胞凋亡，可用于急性髓系白血病研究。

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CDK9-IN-24

CDK9-IN-24 Chemical Structure

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CDK9-IN-24 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK9-IN-24 (compound 21a) is a highly selective CDK9 inhibitor with significant inhibitory effect on tumor growth. CDK9-IN-24 effectively blocks cell proliferation and induces apoptosis by downregulating Mcl-1 and c-Myc, and can be used in acute myeloid leukemia research[1].

IC50 & Target

CDK9

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.7 μM
Compound: 21a
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
BT-549 IC50
0.21 μM
Compound: 21a
Antiproliferative activity against human BT-549 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human BT-549 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
CWR22R IC50
1.25 μM
Compound: LWT-111
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 37672930]
HCT-116 IC50
0.02 μM
Compound: 21a
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
HEK293 IC50
10.7 μM
Compound: 21a
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
HL-60 IC50
0.18 μM
Compound: 21a
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
HT-29 IC50
1.06 μM
Compound: 21a
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
HepG2 IC50
0.41 μM
Compound: 21a
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
L02 IC50
10.6 μM
Compound: 21a
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
MCF7 IC50
0.14 μM
Compound: 21a
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
MOLM-13 IC50
0.16 μM
Compound: 21a
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
MV4-11 IC50
0.06 μM
Compound: 21a
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
SW480 IC50
3.45 μM
Compound: 21a
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
THP-1 IC50
0.45 μM
Compound: 21a
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs
[PMID: 37572539]
分子量

461.55

Formula

C27H31N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK9-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-24CDKApoptosisCyclin dependent kinaseCDK9 inhibitorInhibitorinhibitorinhibit

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目录号：
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