2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. CGP-49823

CGP-49823 是一种口服有效的、高选择性的神经激肽 1 受体 (NK1 receptor) 拮抗剂。CGP-49823 及其他 NK1 受体拮抗剂在沙鼠离体脊髓上的效价显著高于在大鼠离体脊髓上的效价。CGP 49823 在大鼠社会交互实验中具有显著的抗焦虑作用，且其耐受性发展较慢，停药后不产生焦虑样戒断反应。CGP-49823 可用于抗焦虑/抗抑郁研究。

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CGP-49823

CGP-49823 Chemical Structure

CAS No. : 150705-88-7

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CGP-49823 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

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NK1R NK2R NK3R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor). CGP-49823 and other NK1 receptor antagonists‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research[1].

分子量

463.61

Formula

C31H33N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CGP-49823 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP-49823150705-88-7CGP49823CGP 49823Neurokinin ReceptorNK receptorTachykinin receptortachykinin NK1 receptorsubstance Pspinal cordmotoneuronesspecies differenceelectrophysiologyInhibitorinhibitorinhibit

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产品名称：
CGP-49823
目录号：
HY-19203
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