2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. Chlamydocin

Chlamydocin，一种真菌代谢产物，是一种高效的 HDAC 抑制剂，IC50 为 1.3 nM。Chlamydocin 具有很强的抗增殖和抗癌活性。Chlamydocin 通过激活 caspase-3 诱导细胞凋亡。

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Custom Peptide Synthesis

Chlamydocin Chemical Structure

Chlamydocin Chemical Structure

CAS No. : 53342-16-8

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规格 价格 是否有货 数量
1 mg ￥8381
3 - 4 周
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Chlamydocin 相关抗体

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查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].

IC50 & Target[1]

HDAC

1.3 nM (IC50)

体外研究
(In Vitro)

Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chlamydocin 相关抗体:
分子量

526.62

Formula

C28H38N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chlamydocin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Chlamydocin53342-16-8HDACApoptosisHistone deacetylasescyclictetrapeptidaccumulationhyperacetylatedhistonesH3H4A2780ovariancancercellsInhibitorinhibitorinhibit

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