1. Protein Tyrosine Kinase/RTK Apoptosis
  2. FLT3 Apoptosis
  3. CHMFL-FLT3-122

CHMFL-FLT3-122 是一种有效的、选择性的、具有口服活性的 FLT3 激酶,IC50 为 40 nM。CHMFL-FLT3-122 对 FLT3 的选择性优于 BTK (IC50 为 421 nM) 和 c-KIT (IC50 为 559 nM) 激酶。CHMFL-FLT3-122 通过将细胞周期阻滞至 G0/G1 期来诱导细胞凋亡 (apoptosis)。

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CHMFL-FLT3-122 Chemical Structure

CHMFL-FLT3-122 Chemical Structure

CAS No. : 1839150-56-9

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5 mg ¥1960
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10 mg ¥2940
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50 mg ¥7700
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHMFL-FLT3-122 is a potent, selective and orally active FLT3 kinase with an IC50 of 40 nM. CHMFL-FLT3-122 shows selectivity for FLT3 over BTK (IC50 of 421 nM) and c-KIT (IC50 of 559 nM) kinases. CHMFL-FLT3-122 induces apoptosis by arresting the cell cycle into the G0/G1 phase[1].

IC50 & Target

IC50: 40 nM (FLT3 kinase), 421 nM (BTK), 559 nM (c-KIT)[1]

体外研究
(In Vitro)

CHMFL-FLT3-122(化合物18)显着抑制FLT3-ITD阳性急性髓性白血病(AML)癌细胞系MV4-11(GI50 = 22 nM)、MOLM13/14(GI50 = 21 nM/42 nM)的增殖[1]
CHMFL-FLT3-122(0.03-1 μM;24 小时)可以阻止这些细胞系的细胞周期进展至 G0/G1 期并诱导细胞凋亡[1]
CHMFL-FLT3-122 (0.03-1 μM; 24 h) 显着抑制 FLT3 Tyr589/591 位点的自磷酸化,并抑制 Stat5 ERK、AKT 的磷酸化和 cMYC[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MV4-11, MOML14 and MOLM13 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM, 1 μM
Incubation Time: 24 h
Result: Arrested cell cycle progression.

Western Blot Analysis[1]

Cell Line: MV4-11, MOML14 and MOLM13 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM, 1 μM
Incubation Time: 24 h
Result: Significantly affected FLT3 auto-phosphorylation at Tyr589/591 site.
体内研究
(In Vivo)
分子量

471.55

Formula

C26H29N7O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

CHMFL-FLT3-122 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CHMFL-FLT3-122
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HY-110293
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