1. MAPK/ERK Pathway
  2. KLF
  3. CID 5951923

CID 5951923 

目录号: HY-W011044
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CID 5951923是一种有效的 Krüppel-like factor 5 (KLF5) 抑制剂,IC50 值为 603 nM,CID 5951923 可在体外抑制癌细胞的增殖。

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CID 5951923 Chemical Structure

CID 5951923 Chemical Structure

CAS No. : 749872-43-3

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Description

CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1].

IC50 & Target

IC50: 603 nM (KLF5)[1]

In Vitro

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1].

Cell Viability Assay[1]

Cell Line: DLD-1 and IEC-6 cells
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 h
Result: Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.
Molecular Weight

382.39

Formula

C₁₆H₁₈N₂O₇S

CAS No.

749872-43-3

SMILES

O=C(OCC(N(C)C(CC1)CS1(=O)=O)=O)/C=C/C2=CC=CC([N+]([O-])=O)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
C1   V1   C2   V2

Keywords:

CID 5951923CID5951923CID-5951923KLFKrüppel-like factorKrüppel-likefactor5transcriptionKLF5cancerInhibitorinhibitorinhibit

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产品名称:
CID 5951923
目录号:
HY-W011044
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