2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Endogenous Metabolite Antibiotic Apoptosis
  4. Citric acid monohydrate

Citric acid monohydrate  (Synonyms: 一水柠檬酸)

目录号: HY-N1428A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Citric acid monohydrate 是一种天然防腐剂和食品酸味增强剂。Citric acid monohydrate诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期和 S 期。Citric acid monohydrate 通过降低抗氧化酶活性引起肝脏的氧化损伤。Citric acid monohydrate 对小鼠造成肾毒性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Citric acid monohydrate Chemical Structure

Citric acid monohydrate Chemical Structure

CAS No. : 5949-29-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
5 g ￥200
In-stock
10 g ￥350
In-stock
50 g   询价  

* Please select Quantity before adding items.

Other Forms of Citric acid monohydrate:

Citric acid monohydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Citric acid monohydrate (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].
Citric acid monohydrate (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Citric acid monohydrate (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Citric acid monohydrate 相关抗体:

Cell Viability Assay[3]

Cell Line: HaCaT cells
Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time: 24 h
Result: Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 0, 12, 24, 48, 72 h
Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.

Western Blot Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 12, 24, 48 h
Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
体内研究
(In Vivo)

Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1].
Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20 g male Kunming mice[2]
Dosage: 120, 240, 480 mg/kg
Administration: I.p.; weekly for 3 weeks
Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
Clinical Trial
分子量

210.14

Formula

C6H10O8
CAS 号
性状

固体

颜色

White to off-white

中文名称

一水柠檬酸
结构分类
初始来源

Aspergillus niger
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (475.87 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.7587 mL 23.7937 mL 47.5873 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (173 KB) HNMR (106 KB)

产品使用指南 (1538 KB)
参考文献

Citric acid monohydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7587 mL 23.7937 mL 47.5873 mL 118.9683 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL 23.7937 mL
10 mM 0.4759 mL 2.3794 mL 4.7587 mL 11.8968 mL
15 mM 0.3172 mL 1.5862 mL 3.1725 mL 7.9312 mL
20 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9484 mL
25 mM 0.1903 mL 0.9517 mL 1.9035 mL 4.7587 mL
30 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9656 mL
40 mM 0.1190 mL 0.5948 mL 1.1897 mL 2.9742 mL
50 mM 0.0952 mL 0.4759 mL 0.9517 mL 2.3794 mL
60 mM 0.0793 mL 0.3966 mL 0.7931 mL 1.9828 mL
80 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4871 mL
100 mM 0.0476 mL 0.2379 mL 0.4759 mL 1.1897 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Citric acid5949-29-1一水柠檬酸Endogenous MetaboliteAntibioticApoptosisantioxidativeapoptosisrenal toxicityMDA levelsmOxidative damageG2/M phaseS phaseHaCaT cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Citric acid monohydrate
目录号：
HY-N1428A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z