1. Cell Cycle/DNA Damage Stem Cell/Wnt
  2. Casein Kinase
  3. CK2 inhibitor 3

CK2 inhibitor 3 是一种有效的 CK2 抑制剂,IC50 为 280 nM。CK2 inhibitor 3 可抑制细胞内的 CK2,显著影响肿瘤细胞的活力,并对一组 320 激酶显示出显著的选择性。

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CK2 inhibitor 3 Chemical Structure

CK2 inhibitor 3 Chemical Structure

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  • 生物活性

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  • 参考文献

生物活性

CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases[1].

IC50 & Target[1]

CK2

280 nM (IC50)

体外研究
(In Vitro)

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: Jurkat cells[1]
Concentration: 0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time: 24 hours
Result: Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.

Western Blot Analysis

Cell Line: Jurkat cells[1]
Concentration: 5 μM and 20 μM
Incubation Time: 16 hours
Result: Decreased the CK2-dependent phospho-site Akt Ser129 level.
分子量

381.20

Formula

C13H9BrN4O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

CK2 inhibitor 3 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CK2 inhibitor 3
目录号:
HY-143461
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