2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CK2 inhibitor 3

CK2 inhibitor 3 是一种有效的 CK2 抑制剂，IC50 为 280 nM。CK2 inhibitor 3 可抑制细胞内的 CK2，显著影响肿瘤细胞的活力，并对一组 320 激酶显示出显著的选择性。

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CK2 inhibitor 3

CK2 inhibitor 3 Chemical Structure

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CK2 inhibitor 3 相关抗体

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CK1 CK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CK2 inhibitor 3 is a potent CK2 inhibitor with IC50 value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases[1].

IC50 & Target[1]

CK2

280 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Jurkat DC50
12.8 μM
Compound: 4
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay
[PMID: 32283296]
体外研究
(In Vitro)

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC50 value is 12.80 μM[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CK2 inhibitor 3 相关抗体:

Cell Viability Assay

Cell Line: Jurkat cells[1]
Concentration: 0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time: 24 hours
Result: Significantly reduced cell viability in a dose-dependent manner, and DC50 value was 12.80 μM.

Western Blot Analysis

Cell Line: Jurkat cells[1]
Concentration: 5 μM and 20 μM
Incubation Time: 16 hours
Result: Decreased the CK2-dependent phospho-site Akt Ser129 level.
分子量

381.20

Formula

C13H9BrN4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CK2 inhibitor 3 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK2 inhibitor 3Casein KinaseProtein kinase CK2320 protein kinasesCancerCell ViabilityJurkat cellsInhibitorinhibitorinhibit

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CK2 inhibitor 3
目录号：
HY-143461
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