2. PI3K/Akt/mTOR MAPK/ERK Pathway
  3. mTOR Ribosomal S6 Kinase (RSK)
  4. Coronarin A

Coronarin A 是一种具有口服活性的天然物，可抑制 mTORC1 和 S6K1 增加 IRS1 活性。Coronarin A 具有抗炎活性，也可用于糖尿病的研究。

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Coronarin A Chemical Structure

Coronarin A Chemical Structure

CAS No. : 119188-33-9

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Coronarin A 相关抗体

Top Publications Citing Use of Products

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mTOR mTORC1 mTORC2

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p70S6K RSK1 RSK2 RSK3 RSK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

IC50 & Target[1]

mTORC1

 

S6K1

 

体外研究
(In Vitro)

Coronarin A (3-30 μM; 4 or 12 h) stimulates glycogen synthesis through activating PI3K/Akt/GSK3β signaling and inhibits gluconeogenesis by activating ERK-dependent Wnt/β-catenin/TCF7L2 pathway in rat primary hepatocytes[1].
Coronarin A (1-30 μM; 4 h) increases tyrosine phosphorylation of IRS1 through inhibiting mTOR/S6K1 signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Coronarin A 相关抗体:

Western Blot Analysis[1]

Cell Line: Primary rat hepatocytes
Concentration: 1, 3, 10 and 30 μM
Incubation Time: 4 h
Result: Increased the Akt and GSK3β phosphorylation dose-dependently. Dose-dependently stimulated the phosphorylation of both ERK1 and ERK2. Increased the phosphorylation of β-catenin and mitogen-activated protein kinase kinase (MEK). Dose-dependently enhanced the tyrosine phosphorylation of IRS1 at Tyr1222, whereas the serine phosphorylation of IRS1 was dose-dependently inhibited. Reduced the phosphorylation of mTOR, S6K1 and S6.

Cell Viability Assay[1]

Cell Line: Primary rat hepatocytes
Concentration: 1, 3, 10, 30, 100 and 300 μM
Incubation Time: 5.5 h or 12 h
Result: Showed no toxicity at 1-30 μM, decreased cell viability after 12 h incubation at 100 μM.
体内研究
(In Vivo)

Coronarin A (30 or 100 mg/kg; i.p. or p.o.; once daily for 22 days) ameliorates hyperglycemia in mice[1].
Coronarin A (100 mg/kg; p.o.; once daily for 22 days) inhibits the mTOR/S6K1 pathway to activate PI3K/Akt and ERK/β-catenin signaling in livers of ob/ob mice[1].
Pharmacokinetic properties of Coronarin A after single administrationa in ob/ob mice[1].

Coronarin A t1/2 (h) tmax (h) Cmax (ng/mL) AUC0-t (ng⋅h/mL) AUC0-∞ (ng⋅h/mL) MRT (h)
i.p. 14.8 1.0 1073 4571 11045 21.7
p.o. 3.01 1.0 388 1694 1856 4.88

Data are presented as the mean of three mice.
aCoronarin A was intraperitoneally or orally administered at 30 mg/kg to ob/ob mice.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ob/ob mice[1]
Dosage: 30 mg/kg (IP) or 100 mg/kg (PO)
Administration: Oral or intraperitoneal administration, once daily for 22 days
Result: Significantly decreased the non-fasting and fasting blood glucose. Significantly reduced the serum insulin concentration at 15 min after glucose loading, reduced the average daily food intake while the body weight was unaffected. Increased hepatic glycogen content and the expression levels of gluconeogenic gene Pck1 and G6pc were significantly decreased.
Animal Model: Female ob/ob mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal or oral administration (Pharmacokinetic Analysis)
Result: Intraperitoneal injection exhibited higher plasma exposure than oral gavage at the same dose of 30 mg/kg, with Cmax value of 1073 and 388 ng/mL, respectively.
分子量

300.44

Formula

C20H28O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Coronarin A 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coronarin A119188-33-9mTORRibosomal S6 Kinase (RSK)Mammalian target of RapamycinS6KT2DMtype 2 diabetes mellitusgluconeogenesisglycogen synthesisMEKERK1/2β-cateninTCF7L2PI3K/Akt/GSK3βERK/Wnt/β-cateninIRS1mTORC1S6K1Inhibitorinhibitorinhibit

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