2. Immunology/Inflammation Apoptosis
  3. COX Apoptosis
  4. COX-2-IN-43

COX-2-IN-43 (Compound MYM4) 是一种 COX-2 抑制剂 (IC50: 对 COX-1 和 COX-2 分别为 0.983 和 0.247 μM)。COX-2-IN-43 抑制癌细胞增殖和定植，诱导细胞凋亡 (Apoptosis)。

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COX-2-IN-43

COX-2-IN-43 Chemical Structure

CAS No. : 1023524-40-4

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COX-2-IN-43 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2-IN-43 (Compound MYM4) is a COX-2 inhibitor (IC50: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis[1].

IC50 & Target[1]

COX-1

0.983 μM (IC50)

COX-2

0.247 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 IC50
10.22 μM
Compound: MYM4
Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
HEK-293T IC50
216.97 μM
Compound: MYM4
Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
HeLa IC50
1.57 μM
Compound: MYM4
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
Hep 3B2 IC50
4.84 μM
Compound: MYM4
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
HepG2 IC50
29.174 μM
Compound: MYM4
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
LX-2 IC50
20.01 μM
Compound: MYM4
Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
MCF7 IC50
20.72 μM
Compound: MYM4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 38626522]
体外研究
(In Vitro)

COX-2-IN-43 抑制 CaCo-2, Hep3B, and HeLa 癌细胞的增殖, IC50 分别为 10.22, 4.84, and 1.57 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2-IN-43 相关抗体:
分子量

431.19

Formula

C18H11Cl2F3N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2-IN-43 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-431023524-40-4COXApoptosisCyclooxygenaseHeLaHepG2CaCo-2Hep3BanticancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-163509
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