2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. CP-615003

CP-615003 是一种强效、亚型选择性的 GABAA 受体 (GABAA receptor) 部分激动剂 (Ki = 1.1 μM)。CP-615003 在猴和人体中主要通过氧化脱氨生成活性代谢物 CP-900725，后者同样具有 GABAA 受体亲和力。CP-615003 是P-糖蛋白 (P-gp/MDR1) 的底物，造成其中枢神经系统 (CNS) 穿透性严重受限。CP-615003可用于研究 CNS 相关适应症。

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CP-615003

CP-615003 Chemical Structure

CAS No. : 329016-45-7

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CP-615003 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-615003 is a potent and subtype-selective partial agonist of GABAA receptor (GABAA receptor) (Ki = 1.1 μM). CP-615003 is mainly converted into the active metabolite CP-900725 through oxidative deamination in monkeys and humans, and the latter also has GABAA receptor affinity. CP-615003 is a substrate of P-glycoprotein (P-gp/MDR1), resulting in severe limitation of its penetration into the central nervous system (CNS). CP-615003 can be used for the study of CNS-related indications[1].

分子量

373.42

Formula

C20H24FN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-615003 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-615003329016-45-7NGD-913CP615003CP 615003NGD913NGD 913GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorP-glycoprotein (P-gp)CNS penetrationcerebrospinal fluid (CSF)brain extracellular fluid (ECF)multidrug resistance protein 1 (MDR1)pharmacokineticsreceptor occupancy projectionInhibitorinhibitorinhibit

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产品名称：
CP-615003
目录号：
HY-165444
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