CTC 96 

CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research^[1][2].

CTC 96 (0-50 μg/mL，1 小时) 能有效抑制 Vero 细胞中 HSV-1、水痘-带状疱疹病毒 (VZV) 和水疱性口炎病毒 (VSV) 的感染^[1]。
CTC 96 (50 μg/mL，1 小时) 特异性阻断病毒进入细胞的膜融合步骤，但不影响 HSV-1 病毒颗粒与 Vero 细胞表面的黏附^[1]。
CTC 96 (50 μg/mL) 能有效阻断病毒进入细胞，完全中断病毒基因组的释放以及随后在 Vero 细胞中的病毒基因表达过程^[1]。
CTC 96 (50 μg/mL，16 小时) 能有效抑制病毒在已感染 Vero 细胞间的直接传播^[1]。
CTC-96 (0-250 μg/mL，1 小时) 在 HeLa、A549 和 SIRC 细胞系的组织培养中显示出对 Ad5 的杀灭病毒活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CTC 96 (25-50 μg/mL，滴眼，每日 6-9 次，持续 13-21 天) 可显著缓解兔眼腺病毒诱导的角膜和结膜炎症模型中的结膜炎临床症状^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

525.33

C₂₀H₃₀BrCoN₆O₂

149754-11-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schwartz JA, Lium EK, Silverstein SJ. Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96. J Virol. 2001 May;75(9):4117-28.  [Content Brief]

  [2]. Epstein SP, et al. Efficacy of topical cobalt chelate CTC-96 against adenovirus in a cell culture model and against adenovirus keratoconjunctivitis in a rabbit model. BMC Ophthalmol. 2006 Jun 5;6:22.  [Content Brief]