2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450
  4. CYP51-IN-26

CYP51-IN-26 是一种 CYP51 抑制剂，其 IC50 值约为 0.40 μM。CYP51-IN-26 可根除耳念珠菌生物膜。CYP51-IN-26 在累积实验中显著改善细胞摄取能力。CYP51-IN-26 在 G. mellonella 和 D. melanogaster 模型中均能保护免受耳念珠菌感染。CYP51-IN-26 可用于真菌感染研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CYP51-IN-26

CYP51-IN-26 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CYP51-IN-26 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections[1].

体外研究
(In Vitro)

CYP51-IN-26 (Compound 7) 在耳念珠菌菌株 TDG1912 中的积累水平显著高于 Fluconazole (HY-B0101)[1]。
CYP51-IN-26 对以下菌株显示出抗真菌活性：C.albicans NCNCPF3281(0.125 μg/mL)、N.glabratus NCPF8018 (0.25 μg/mL)、C.tropicalis NCPF8760 (0.25 μg/mL)、C.parapsilosis NCPF3209 (0.125 μg/mL)、TDG19 12 (0.25 μg/mL)、TDG25 12 (0.06 μg/mL)、TDG11 02 (4 μg/mL)、TDG22 11 (0.5 μg/mL)、TDG25 06 (≤ 0.03 μg/mL)、NCPF89 84 (≤ 0.03 μg/mL)、NCPF8971 (≤ 0.25 μg/mL) 和 NCPF8977 (≤ 0.03 μg/mL)[1]。
CYP51-IN-26 (0.03-64 μg/mL, 24 h) 显著降低生物膜生物量，表现出与 Voriconazole (HY-76200) 相当的清除活性[1]。
CYP51-IN-26 (0-25 h) 在至少 6 小时的孵育时间内显示出对耳念珠菌 TDG1912 生长的抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYP51-IN-26 相关抗体:
体内研究
(In Vivo)

CYP51-IN-26 (Compound 7) (10-50 mg/kg，局部注射，感染后 30 分钟注射一次) 在感染了耳念珠菌 (TDG1912) 的大蜡螟 (G. mellonella) 模型中显示出显著的抗真菌效果[1]。
CYP51-IN-26 (5-50 mg/kg，局部注射，感染后 1 小时注射一次) 在感染耳念珠菌的黑腹果蝇模型中改善了存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: G. mellonella larvae were injected with 10 μL of C.auris strain TDG1912 at 1 × 107 CFU/mL into the first left proleg[1]
Dosage: 10, 20, 50 mg/kg
Administration: Local injected once after infection 30 min
Result: Demonstrated significant antifungal efficacy at 50 mg/kg and 20 mg/kg doses.
Animal Model: D.melaogaster adults were injected with 10 nL of C.auris strain TDG1912 at a concentration of 2 × 1011 CFU/mL or 1 × 1012 CFU/mL into the dorsolateral thorax below the right wing hinge[1]
Dosage: 5, 20, 50 mg/kg
Administration: Local injected once after infection 1 h
Result: Improved survival at both 50 and 20 mg/kg compared to the untreated group.
分子量

433.43

Formula

C20H22F3N7O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP51-IN-26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP51-IN-26FungalCytochrome P450CYPsCYP51fungal infectionG. mellonellaD. melanogasterC. aurisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CYP51-IN-26
目录号：
HY-174973
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z