2. Metabolic Enzyme/Protease Cytoskeleton
  3. MMP Cadherin
  4. Cystatin B agonist 1

Cystatin B agonist 1 是一种具有口服活性的 MMP-2/9 抑制剂。Cystatin B agonist 1 对 U87 和 T98G 细胞表现出抑制作用，其 IC50 值分别为 3.95 μM 和 3.43 μM。Cystatin B agonist 1 诱导 MG 细胞 S 期细胞周期阻滞并抑制其血管生成，迁移和侵袭。Cystatin B agonist 1 抑制 U87 MG 异种移植模型中的肿瘤生长。Cystatin B agonist 1 可用于恶性胶质瘤 (MG) 的研究。

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Cystatin B agonist 1

Cystatin B agonist 1 Chemical Structure

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Cystatin B agonist 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cystatin B agonist 1 is an orally active MMP-2/9 inhibitor. Cystatin B agonist 1 exhibits inhibitory effects with IC50 values of 3.95 and 3.43 μM against U87 and T98G cells, respectively. Cystatin B agonist 1 induces the cell-cycle arrest at S phase, inhibits angiogenesis, and suppresses migration and invasion of MG cells. Cystatin B agonist 1 inhibits tumor growth in U87 MG xenograft model. Cystatin B agonist 1 can be used for the study of malignant glioma (MG)[1].

体外研究
(In Vitro)

Cystatin B agonist 1 (Compound 1e) (2.5-6 μM，14 天) 以浓度依赖的方式抑制 U87 和 U251 细胞的克隆形成[1]。
Cystatin B agonist 1(2.5-6 μM，24 h) 在 U87 和 U251 细胞中诱导 S 期阻滞[1]。
Cystatin B agonist 1 (2-6 μM，6 h) 减弱 U87 和 HUVEC 细胞的管形成能力[1]。
Cystatin B agonist 1 (2.5-6 μM，6-24 h) 抑制 MG 细胞系 (U87 和 U251 细胞) 的迁移和侵袭[1]。
Cystatin B agonist 1 (5-6 μM) 增加 U87 和 U251 细胞中 E-cadherin 的表达，降低 Vimentin 和基质金属蛋白酶 (MMPs) 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cystatin B agonist 1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 24 h
Result: Induced S cycle arrest in U87 and U251 cells.

Cell Migration Assay [1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 24 h
Result: Inhibited migration in U87 and U251 cells.

Cell Invasion Assay[1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 48 h
Result: Inhibited invasion in U87 and U251 cells.
体内研究
(In Vivo)

Cystatin B agonist 1 (Compound 1e) (50-100 mg/kg，灌胃给药，连续给药 5 天，间隔 2 天，持续 21 天) 在 U87 MG 异种移植模型中显示出卓越的抗肿瘤效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (18-20 g, 6-8 weeks old) were injected subcutaneously with U87 cells suspended in 100 μL PBS (1 × 107 cells/mL)[1]
Dosage: 50,100 mg/kg
Administration: Oral gavage for five consecutive days and two-day intervals for 3 weeks
Result: Reduced tumor growth.
Showed no significant changes in body weight.
Decreased the levels of Ki-67, Vimentin, and MMP2 proteins.
分子量

344.36

Formula

C19H20O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cystatin B agonist 1 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cystatin B agonist 1Cystatin B agonist1Cystatin B agonist-1MMPCadherinMatrix metalloproteinasesMMP-2/9malignant gliomaU87 cellsT98G cellsInhibitorinhibitorinhibit

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