2. Metabolic Enzyme/Protease Cytoskeleton
  3. MMP Cadherin
  4. Cystatin B agonist 1

Cystatin B agonist 1 是一种具有口服活性的 MMP-2/9 抑制剂。Cystatin B agonist 1 对 U87 和 T98G 细胞表现出抑制作用，其 IC50 值分别为 3.95 μM 和 3.43 μM。Cystatin B agonist 1 诱导 MG 细胞 S 期细胞周期阻滞并抑制其血管生成，迁移和侵袭。Cystatin B agonist 1 抑制 U87 MG 异种移植模型中的肿瘤生长。Cystatin B agonist 1 可用于恶性胶质瘤 (MG) 的研究。

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Cystatin B agonist 1

Cystatin B agonist 1 Chemical Structure

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Cystatin B agonist 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cystatin B agonist 1 is an orally active MMP-2/9 inhibitor. Cystatin B agonist 1 exhibits inhibitory effects with IC50 values of 3.95 and 3.43 μM against U87 and T98G cells, respectively. Cystatin B agonist 1 induces the cell-cycle arrest at S phase, inhibits angiogenesis, and suppresses migration and invasion of MG cells. Cystatin B agonist 1 inhibits tumor growth in U87 MG xenograft model. Cystatin B agonist 1 can be used for the study of malignant glioma (MG)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.2 μM
Compound: 1q
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35090346]
NCI-H460 IC50
3 μM
Compound: 1q
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35090346]
体外研究
(In Vitro)

Cystatin B agonist 1 (Compound 1e) (2.5-6 μM，14 天) 以浓度依赖的方式抑制 U87 和 U251 细胞的克隆形成[1]。
Cystatin B agonist 1(2.5-6 μM，24 h) 在 U87 和 U251 细胞中诱导 S 期阻滞[1]。
Cystatin B agonist 1 (2-6 μM，6 h) 减弱 U87 和 HUVEC 细胞的管形成能力[1]。
Cystatin B agonist 1 (2.5-6 μM，6-24 h) 抑制 MG 细胞系 (U87 和 U251 细胞) 的迁移和侵袭[1]。
Cystatin B agonist 1 (5-6 μM) 增加 U87 和 U251 细胞中 E-cadherin 的表达，降低 Vimentin 和基质金属蛋白酶 (MMPs) 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cystatin B agonist 1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 24 h
Result: Induced S cycle arrest in U87 and U251 cells.

Cell Migration Assay [1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 24 h
Result: Inhibited migration in U87 and U251 cells.

Cell Invasion Assay[1]

Cell Line: U87 and U251 cells
Concentration: 2.5, 3, 5, 6 μM
Incubation Time: 48 h
Result: Inhibited invasion in U87 and U251 cells.
体内研究
(In Vivo)

Cystatin B agonist 1 (Compound 1e) (50-100 mg/kg，灌胃给药，连续给药 5 天，间隔 2 天，持续 21 天) 在 U87 MG 异种移植模型中显示出卓越的抗肿瘤效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (18-20 g, 6-8 weeks old) were injected subcutaneously with U87 cells suspended in 100 μL PBS (1 × 107 cells/mL)[1]
Dosage: 50,100 mg/kg
Administration: Oral gavage for five consecutive days and two-day intervals for 3 weeks
Result: Reduced tumor growth.
Showed no significant changes in body weight.
Decreased the levels of Ki-67, Vimentin, and MMP2 proteins.
分子量

344.36

Formula

C19H20O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cystatin B agonist 1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cystatin B agonist 1Cystatin B agonist1Cystatin B agonist-1MMPCadherinMatrix metalloproteinasesMMP-2/9malignant gliomaU87 cellsT98G cellsInhibitorinhibitorinhibit

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