1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Thalidomide-O-amido-C4-NH2

Thalidomide-O-amido-C4-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 6; E3 Ligase Ligand-Linker Conjugates 19)

目录号: HY-107438
产品使用指南

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。

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Thalidomide-O-amido-C4-NH2 Chemical Structure

Thalidomide-O-amido-C4-NH2 Chemical Structure

CAS No. : 1799711-24-2

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Thalidomide-O-amido-C4-NH2 的其他形式现货产品:

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查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

Thalidomide-O-amido-C4-NH2 is an amine intermediate (Compound 41), which can be used as is a heterobifunctional PROTAC BET degrader. The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases. Recently, heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation[1]. Thalidomide-O-amido-C4-NH2 is a degron-linker (refer to Compound DL6-TL). Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

402.40

Formula

C19H22N4O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Thalidomide-O-amido-C4-NH2
目录号:
HY-107438
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