2. PI3K/Akt/mTOR Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis
  4. Dichloroacetic acid

Dichloroacetic acid  (Synonyms: DCAA; Dichloracetic acid)

目录号: HY-Y0445
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Dichloroacetic acid (DCAA) 是具有口服活性的丙酮酸脱氢酶激酶 (PDK) 抑制剂。Dichloroacetic acid 还能刺激丙酮酸脱氢酶 (PDH) 活性，并作为 Na+-K+-2Cl- 共转运蛋白 (NKCC) 抑制剂。Dichloroacetic acid 阻止 PDC 的 E1α 亚基的磷酸化，促进丙酮酸进入线粒体进行氧化代谢，减少乳酸生成，同时增加活性氧 (ROS) 的产生。Dichloroacetic acid 抑制肿瘤细胞增殖，并诱导凋亡 (apoptosis)。Dichloroacetic acid 有望用于癌症的研究。

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Dichloroacetic acid

Dichloroacetic acid Chemical Structure

CAS No. : 79-43-6

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Dichloroacetic acid 的其他形式现货产品:

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Dichloroacetic acid 相关抗体

Top Publications Citing Use of Products

    Dichloroacetic acid purchased from MCE. Usage Cited in: Life Sci. 2023 Jan 1:312:121192.

    Sodium dichloroacetate (DCA; 10 mM; 48 h) significantly inhibits hypoxia-induced proliferation of HPASMCs (Fig I) , and markedly increases the apoptosis rate (Fig J).

    • 生物活性

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    • 参考文献

    生物活性

    Dichloroacetic acid (DCAA) is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Dichloroacetic acid also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na+-K+-2Cl− cotransporter (NKCC) inhibitor. Dichloroacetic acid prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Dichloroacetic acid inhibits tumor cell proliferation and induces apoptosis. Dichloroacetic acid is promising for research of cancers[1][2].

    分子量

    128.94

    Formula

    C2H2Cl2O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Dichloroacetic acid 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dichloroacetic acid79-43-6DCAA Dichloracetic acidPDK-1NKCCPDHKReactive Oxygen Species (ROS)Apoptosis3-Phosphoinositide-dependent protein kinase 1Na-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporter Pyruvate dehydrogenase kinasePDH kinaseorally activePDKPDHROStumor cellcancersInhibitorinhibitorinhibit

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