2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Dicloxacillin

Dicloxacillin  (Synonyms: 双氯西林)

目录号: HY-B1459A
产品使用指南 技术支持

Dicloxacillin 是青霉素类的 β 内酰胺抗生素 (β-lactam antibiotic)，可用于革兰氏阳性菌感染的研究, 有效抑制 β-内酰胺酶产生的微生物如金黄色葡萄球菌。

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Dicloxacillin

Dicloxacillin Chemical Structure

CAS No. : 3116-76-5

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规格 价格 是否有货 数量
5 mg ￥650
1 - 2 周
10 mg ￥1050
1 - 2 周
25 mg ￥2100
1 - 2 周
50 mg ￥3350
1 - 2 周
100 mg ￥5400
1 - 2 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Dicloxacillin:

Dicloxacillin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 Beta-lactamase 亚型特异性产品:

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[1].

IC50 & Target

β-lactam

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
16.6 μM
Compound: Dicloxacillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
Sf21 IC50
111.1 μM
Compound: Dicloxacillin
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
Sf21 IC50
69.7 μM
Compound: Dicloxacillin
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
THP-1 EC50
0.04 mg/L
Compound: DCX
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
THP-1 EC50
0.31 mg/L
Compound: DCX
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
体外研究
(In Vitro)

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dicloxacillin 相关抗体:
体内研究
(In Vivo)

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[3].
Dosage: 125 mg/kg.
Administration: IV injection, single doses.
Result: All the mice survived.
Clinical Trial
分子量

470.33

Formula

C19H17Cl2N3O5S
CAS 号
中文名称

双氯西林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dicloxacillin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicloxacillin3116-76-5双氯西林Beta-lactamaseBacterialAntibioticβ-lactamaseβ-lactam antibioticpenicillinInhibitorinhibitorinhibit

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