Dihydrokainic acid 

Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory^{[1][2][3][4][5]}.

Dihydrokainic acid (5 mM；处理小脑切片 15 min) 浓度依赖性地抑制小脑切片对 D-[³H] 天冬氨酸的摄取^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrokainic acid (1-10 mM；通过透析探针灌注；持续 60 min；单次给药) 在大鼠齿状回模型中，能诱发癫痫样活动，导致细胞外牛磺酸、丙氨酸、磷酸乙醇胺以及谷氨酸和天冬氨酸浓度增加，同时使群体峰电位幅度增大、PS2:PSI 比值升高^[3]。 Dihydrokainic acid (12.5-25 nmol；单侧脑室内注射；单次给药) 在小鼠新颖物体识别 (NOR) 记忆模型中，会损害短期 NOR 记忆表现、长期 NOR 记忆获取、巩固和检索能力^[4]。 Dihydrokainic acid (1-5mM；通过透析电极灌注；15 min；单次给药) 在大鼠海马体 (齿状回或 CA1 区)模型中，可使细胞外谷氨酸和牛磺酸浓度显著增加，在齿状回中降低场兴奋性突触后电位但增大群体峰电位，在 CA1 区则使兴奋性突触后电位和峰电位幅度均降低^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

215.25

C₁₀H₁₇NO₄

52497-36-6

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• [1]. Lehmann A, et al. Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus. Neuroscience Letters, 1983, 38(1): 67-72.

  [2]. Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21(12):1527-33.  [Content Brief]

  [3]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81.  [Content Brief]

  [4]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32.  [Content Brief]

  [5]. Muñoz M D, et al. Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology, 1987, 26(1): 1-8.