2. Apoptosis
  3. Apoptosis
  4. Diselaginellin B

Diselaginellin B (化合物 2) 是从 Selaginella Pulvinata 中分离出的天然产物，对人肝癌细胞具有抗增殖，诱导凋亡 (apoptosis) 和抗转移活性。

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Diselaginellin B

Diselaginellin B Chemical Structure

CAS No. : 1835299-12-1

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Diselaginellin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, apoptosis-inducing and antimetastatic activities against human carcinoma hepatocellular cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SMMC-7721 IC50
9 μM
Compound: 2
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29144743]
体外研究
(In Vitro)

Diselaginellin B (2.5-10 μM) 对 SMMC-7721 细胞具有细胞毒性，IC50 为 9.0 μM，通过上调 DLD 并且抑制 COX-1/2 和 NNMT 的表达，浓度依赖的诱导细胞凋亡[1]。
Diselaginellin B (0.5-2 μM) 下调 TSPAN8 和 MAGP2，抑制血管形成，减少癌细胞转移和侵袭[1]。
Diselaginellin B (2.5-5 μM) 在 G1 期阻滞细胞周期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diselaginellin B 相关抗体:

Cell Invasion Assay[1]

Cell Line: SMMC-7721
Concentration: 0.5-2 μM
Incubation Time: 48 h
Result: Reduced the cancer cells migration and invasion in a dose-dependent manner.

Real Time qPCR[1]

Cell Line: SMMC-7721
Concentration: 8 μM
Incubation Time: 3 days
Result: Upregulated DLD, decreased expressions of COX-1/2, NNMT, TSPAN8 and MAGP2
分子量

1007.09

Formula

C68H46O9
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diselaginellin B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diselaginellin B1835299-12-1ApoptosisSMMC-7721HCCSelaginella PulvinataInhibitorinhibitorinhibit

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