2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Doxapram hydrochloride hydrate

Doxapram hydrochloride hydrate  (Synonyms: 多沙普仑盐酸一水合物)

目录号: HY-B0551A 纯度: 99.34%
COA 产品使用指南

摩尔计算器

Doxapram能抑制TASK-1，TASK-3和TASK-1/TASK-3异二聚体通道，EC50分别为410 nM，37 μM和9 μM。

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Doxapram hydrochloride hydrate Chemical Structure

Doxapram hydrochloride hydrate Chemical Structure

CAS No. : 7081-53-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥858
In-stock
50 mg ￥780
In-stock
100 mg ￥1300
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Doxapram hydrochloride hydrate:

Doxapram hydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Target: Potassium Channel Doxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body [1]. Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the neuronal cell line NG-108 15, suggesting a selective effect on carotid body type I cells. The effects of doxapram on type I cells show similarities to those of the physiological stimuli of the carotid body, suggesting that doxapram may share a similar mechanism of action in stimulating the intact organ [2].

Clinical Trial
分子量

432.98

Formula

C24H33ClN2O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

多沙普仑盐酸一水合物；多沙普伦盐酸一水合物；吗啉吡咯酮盐酸一水合物；吗乙苯吡酮盐酸一水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 55 mg/mL (127.03 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 25 mg/mL (57.74 mM; 超声助溶)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3096 mL 11.5479 mL 23.0958 mL
5 mM 0.4619 mL 2.3096 mL 4.6192 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Doxapram hydrochloride hydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.3096 mL 11.5479 mL 23.0958 mL 57.7394 mL
5 mM 0.4619 mL 2.3096 mL 4.6192 mL 11.5479 mL
10 mM 0.2310 mL 1.1548 mL 2.3096 mL 5.7739 mL
15 mM 0.1540 mL 0.7699 mL 1.5397 mL 3.8493 mL
20 mM 0.1155 mL 0.5774 mL 1.1548 mL 2.8870 mL
25 mM 0.0924 mL 0.4619 mL 0.9238 mL 2.3096 mL
30 mM 0.0770 mL 0.3849 mL 0.7699 mL 1.9246 mL
40 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4435 mL
50 mM 0.0462 mL 0.2310 mL 0.4619 mL 1.1548 mL
DMSO 60 mM 0.0385 mL 0.1925 mL 0.3849 mL 0.9623 mL
80 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.7217 mL
100 mM 0.0231 mL 0.1155 mL 0.2310 mL 0.5774 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxapram hydrochloride7081-53-0多沙普仑盐酸一水合物多沙普伦盐酸一水合物吗啉吡咯酮盐酸一水合物吗乙苯吡酮盐酸一水合物Potassium ChannelKcsAInhibitorinhibitorinhibit

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产品名称：
Doxapram hydrochloride hydrate
目录号：
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