2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis Bcl-2 Family
  4. EGFR-IN-170

EGFR-IN-170 (Compound 5c) 是一种 EGFR 抑制剂，其 IC50 为 5.17 μM。EGFR-IN-170 通过抑制 Bcl2 并激活 Bax 的表达，且显著增加 Bax/Bcl2 的比率来诱导细胞凋亡 (apoptosis)。EGFR-IN-170 具有强大的抗癌活性，可抑制耐药肺癌细胞的生长。

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EGFR-IN-170

EGFR-IN-170 Chemical Structure

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Customer Review

EGFR-IN-170 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-170 (Compound 5c) is an EGFR inhibitor with an IC50 of 5.17 μM. EGFR-IN-170 induces apoptosis by inhibiting Bcl2 expression and activating Bax expression with a significantly increased ratio of Bax/Bcl2. EGFR-IN-170 has potent anticancer activity and inhibits the cell growth of resistant lung cancer cells[1].

IC50 & Target[1]

Bcl-2

 

Bax

 

分子量

585.52

Formula

C27H27N3O12
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-170 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-170EGFRApoptosisBcl-2 FamilyEpidermal growth factor receptorErbB-1HER1Bax/Bcl2AnticancerH1922 cellsH1975 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-175588
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