2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-79

EGFR-IN-79 (compound 21) 是一种具有抗肿瘤活性的 EGFR 抑制剂。EGFR-IN-79 诱导 ROS 依赖性细胞凋亡和 EGFR/AKT/mTOR 介导的自噬。EGFR-IN-79 诱导 EJ28 球体的增殖区和静止区的细胞死亡。EGFR-IN-79 在基于斑马鱼的模型中表现出安全性。

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EGFR-IN-79

EGFR-IN-79 Chemical Structure

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EGFR-IN-79 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
15.1 μM
Compound: 21
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
HT-1080 IC50
13 μM
Compound: 21
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
MCF7 IC50
8.8 μM
Compound: 21
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
NHDF IC50
39.7 μM
Compound: 21
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
SW-620 IC50
10 μM
Compound: 21
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37098306]
分子量

417.84

Formula

C23H16ClN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-79 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-79EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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产品名称：
EGFR-IN-79
目录号：
HY-155074
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