2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-97

EGFR-IN-97 (compound 6q) 是一种 EGFR 抑制剂。EGFR-IN-97 对 Ba/F3-EGFRL858R/T790M/C797S 和 Ba/F3-EGFRDel19/T790M/C797S 细胞显示出抑制活性，IC50 值分别为 0.42 μM 和 0.41 μM。EGFR-IN-97 在0.8 μM 浓度下可促进 NCI-H1975-EGFRL858R/T790M/C797S 细胞凋亡 (apoptosis)。

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EGFR-IN-97

EGFR-IN-97 Chemical Structure

CAS No. : 3020681-05-1

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EGFR-IN-97 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-97 (compound 6q) is a EGFR inhibitor. EGFR-IN-97 shows inhibitory activity against Ba/F3-EGFRL858R/T790M/C797S and Ba/F3-EGFRDel19/T790M/C797S cells, with IC50 values of 0.42 μM and 0.41 μM, respectively. EGFR-IN-97 can promote apoptosis of NCI-H1975-EGFRL858R/T790M/C797S cells at the concentration of 0.8 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
5.14 μM
Compound: 6q
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38142512]
BEAS-2B IC50
5.12 μM
Compound: 6q
Antiproliferative activity against human BEAS-2B cells assessed as inhibition of cell growth
Antiproliferative activity against human BEAS-2B cells assessed as inhibition of cell growth
[PMID: 38142512]
BaF3 IC50
0.41 μM
Compound: 6q
Antiproliferative activity against mouse BaF3 cells harboring EGFR Del19/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring EGFR Del19/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
[PMID: 38142512]
BaF3 IC50
0.41 μM
Compound: 6q
Antiproliferative activity against mouse BaF3 cells harboring wildtype EGFR assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring wildtype EGFR assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
[PMID: 38142512]
BaF3 IC50
0.42 μM
Compound: 6q
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
[PMID: 38142512]
NCI-H1975 IC50
0.82 μM
Compound: 6q
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent assay
[PMID: 38142512]
NCI-H1975 IC50
2.95 μM
Compound: 6q
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38142512]
体外研究
(In Vitro)

EGFR-IN-97 (compound 6q) 对突变型NSCLC细胞系NCI-H1975-EGFRL858R/T790M/C797S细胞表现出优异的活性，IC50值为0.82 μM，优于 osimertinib (HY-15772) (IC50 = 2.94 μM)、JBJ-04-125-02 (HY-135805) (IC50 = 3.66 μM)，以及 JBJ-04-125-02 和 osimertinib 共同给药(IC50 = 1.25 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-97 相关抗体:
分子量

624.73

Formula

C37H36N8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-97 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-973020681-05-1EGFRApoptosisEpidermal growth factor receptorErbB-1HER1NCI-H1975Ba/F3NSCLCInhibitorinhibitorinhibit

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