2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Cytoskeleton PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Autophagy Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. EGFR Microtubule/Tubulin Akt ERK Autophagy Atg8/LC3 p62 Ferroptosis Reactive Oxygen Species (ROS)
  4. EGFR/tubulin-IN-1

EGFR/tubulin-IN-1 (Compound 26) 是一种 EGFR 和 tubulin 双靶点抑制剂。EGFR/tubulin-IN-1 显著降低了细胞中 p-EGFR、p-AKT、p-ERK 的水平，破坏了细胞微管结构。EGFR/tubulin-IN-1 显著抑制 H1975 细胞的增殖，将细胞显著阻滞在 G2/M 期。EGFR/tubulin-IN-1 诱导了自噬 (autophagy) 标志物 LC3B-II 和 Beclin-1 表达上调，p62 表达下调。EGFR/tubulin-IN-1 诱导了细胞铁死亡 (ferroptosis)，ROS 含量升高和谷胱甘肽 (GSH) 耗竭。EGFR/tubulin-IN-1 抑制上皮-间质转化 (EMT) 与肿瘤转移。EGFR/tubulin-IN-1 在 H1975 移植瘤裸鼠模型中具有显著的肿瘤抑制效果。EGFR/tubulin-IN-1 可用于研究非小细胞肺癌。

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EGFR/tubulin-IN-1

EGFR/tubulin-IN-1 Chemical Structure

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EGFR/tubulin-IN-1 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/tubulin-IN-1 (Compound 26) is a dual-target inhibitor of EGFR and tubulin. EGFR/tubulin-IN-1 significantly reduces the levels of p-EGFR, p-AKT, and p-ERK in cells, disrupting the microtubule structure of the cells. EGFR/tubulin-IN-1 significantly inhibits the proliferation of H1975 cells and significantly blocks the cells in the G2/M phase. EGFR/tubulin-IN-1 induces the expression of autophagy markers LC3B-II and Beclin-1, while down-regulating the expression of p62. EGFR/tubulin-IN-1 induces ferroptosis, with increased ROS content and depletion of glutathione (GSH). EGFR/tubulin-IN-1 inhibits epithelial-mesenchymal transition (EMT) and tumor metastasis. EGFR/tubulin-IN-1 has a significant tumor-suppressing effect in the H1975 transplanted tumor nude mouse model. EGFR/tubulin-IN-1 can be used for the study of non-small cell lung cancer[1].

分子量

744.25

Formula

C40H43ClFN5O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/tubulin-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/tubulin-IN-1EGFRMicrotubule/TubulinAktERKAutophagyAtg8/LC3p62FerroptosisReactive Oxygen Species (ROS)Epidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesAutophagy-related 8Sequestosome-1SQSTM1EGFR-TKIsErianinNSCLCInhibitorinhibitorinhibit

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EGFR/tubulin-IN-1
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