2. Epigenetics
  3. Histone Acetyltransferase
  4. Ep300/CREBBP-IN-8

Ep300/CREBBP-IN-8 (Example 37) 是一种有效的和具有口服活性的 Ep300 和 CREBBP 抑制剂，IC50 分别为 0.014 μM 和 0.018 μM。Ep300/CREBBP-IN-8 可用于癌症研究。

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Ep300/CREBBP-IN-8 Chemical Structure

Ep300/CREBBP-IN-8 Chemical Structure

CAS No. : 2259641-24-0

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Ep300/CREBBP-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ep300/CREBBP-IN-8 (Example 37) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.014 and 0.018 μM, respectively. Ep300/CREBBP-IN-8 can be used for the research of cancer[1].

IC50 & Target[1]

EP300

0.014 μM (IC50)

CREBBP

0.018 μM (IC50)

体外研究
(In Vitro)

Ep300/CREBBP-IN-8 (Example 37) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.016 μM[1]。
Ep300/CREBBP-IN-8 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 85.917 μM 和 112.922 μM [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ep300/CREBBP-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: LK2 and TE-8 cells
Concentration: 38 nM-10 mM
Incubation Time: 3 days
Result: Inhibited LK2 and TE-8 cell growth with GI50s of 85.917 and 112.922 μM, respectively.
体内研究
(In Vivo)

Ep300/CREBBP-IN-8 (Example 37; 6.25 mg/kg/day; oral; twice daily for 11 days) 抑制小鼠肿瘤增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu/nu mice, LK2 cell subcutaneous transplant model[1]
Dosage: 6.25 mg/kg/day
Administration: Oral administration, twice a day for 11 days
Result: Inhibited tumor volume by 42%.
分子量

483.51

Formula

C25H27F2N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ep300/CREBBP-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ep300/CREBBP-IN-82259641-24-0Histone AcetyltransferaseHATsHATH3K27AcLK2TE-8Inhibitorinhibitorinhibit

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