2. 疾病领域
  3. 神经系统疾病
  4. ERD03

ERD03 是 EXOSC3-RNA 相互作用的强效破坏剂，其 Kd 值为 17±7 μM。ERD03 诱导斑马鱼胚胎 PCH1B 样表型，可用于脑神经失调的研究。

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ERD03

ERD03 Chemical Structure

CAS No. : 1377897-01-2

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规格 价格 是否有货
1 mg ￥2136
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5 mg ￥4700
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10 mg 询价 询问价格 & 货期

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ERD03 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a Kd of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research[1].

IC50 & Target

Kd: 17±7 μM (EXOSC3-RNA interaction)[1]
体外研究
(In Vitro)

ERD03 inhibits the binding of G-rich RNA and EXOSC3 with ~18% inhibition at 50 μM[1].
ERD03 (50 μM; 5 days) causes significant spinal curvature and recapitulates PCH1B phenotype in development in zebrafish embryos[1].
ERD03 (50 μM) induces a ~6-fold upregulation of ataxin1b mRNA and results in a minor accumulation of ataxin1a mRNA in embryos. ERD03 induces an atrophy of the zebrafish cerebellum and results in zebrafish cerebella half the size of control brains in DMSO[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ERD03 相关抗体:
分子量

339.43

Formula

C21H25NO3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

ERD03 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERD031377897-01-2ERD 03ERD-03OthersEXOSC3-RNAneurological disorderPCH1BPontocerebellar Hypoplasia type 1BInhibitorinhibitorinhibit

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目录号：
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