2. 天然产物
  3. 疾病研究领域 植物 萜类
  4. 七叶树科 炎症/免疫 其他科 三萜
  5. 欧洲七叶树
  6. Escin IIa

Escin IIa 是从欧洲七叶树中分离出来的，对动物急性炎症有积极作用。Escin IIa 对乙醇诱导的胃粘膜损伤有明显的保护作用。

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Escin IIa Chemical Structure

Escin IIa Chemical Structure

CAS No. : 158732-55-9

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Escin IIa 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

体内研究
(In Vivo)

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1]
Dosage: 10-50 mg/kg
Administration: p.o.
Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats.
分子量

1101.23

Formula

C54H84O23
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Keywords:

Escin IIa158732-55-9Othersacuteinflammationgastriclesionsvascularethanol-inducedInhibitorinhibitorinhibit

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