2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR1 inhibitor-2

FGFR1 inhibitor-2 是一个 FGFR1 抑制剂（IC50 为 4.55 μM 在 MDA-MB-231细胞中）。FGFR1 inhibitor-2 可用于转移性三阴性乳腺癌的研究。

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FGFR1 inhibitor-2 Chemical Structure

FGFR1 inhibitor-2 Chemical Structure

CAS No. : 2410612-08-5

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FGFR1 inhibitor-2 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

IC50 & Target[1]

FGFR1

 

体外研究
(In Vitro)

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1].
FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FGFR1 inhibitor-2 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 and 6 μM
Incubation Time: 48 hours
Result: Reduced the expression of FGFR1.
分子量

507.45

Formula

C25H22F5N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGFR1 inhibitor-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR1 inhibitor-22410612-08-5FGFRFibroblast growth factor receptorMDA-MB-231,metastatictriple-negativebreastcancerInhibitorinhibitorinhibit

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