Fluvoxamine-¹³C, d₃ maleate  (Synonyms: 马来酸氟伏沙明-¹³C,d₃; DU-23000-¹³C, d₃ maleate)

Fluvoxamine-¹³C, d₃ maleate is ¹³C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluvoxamine maleate (DU-23000 maleate) 可有效抑制血小板和脑突触体对 5-HT 的摄取。Fluvoxamine maleate 对利血平诱导的五亚甲基四唑惊厥阈值降低的拮抗作用可视为对 5-HT 摄取的影响。与去甲基丙咪嗪和丙咪嗪的作用相反，当在一定剂量的氟伏沙明后给予速效利血平样化合物时，在大鼠中未发现刺激作用^[2]。Fluvoxamine (DU-23000) 似乎可以改善与战斗相关的 PTSD 症状，但不能改善抑郁症状。高流失率和缺乏安慰剂组限制了我们研究的结论。有必要对氟伏沙明处理 PTSD 进行对照研究^[3]。当同时提供食物时与单独提供乙醇时相比，Fluvoxamine maleate (DU-23000) 在减少乙醇自我给药方面的效力较低[ED₅₀：4.0 (2.7-5.9) 和 5.1 (4.3-6.0) ]。在有食物的每种情况下，对食物的影响是相似的。结果表明，Fluvoxamine maleate 在减少乙醇维持行为方面的效力取决于乙醇是单独提供还是在同时安排的食物强化的情况下提供^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

438.42

C₁₈¹³CH₂₂D₃F₃N₂O₆

马来酸氟伏沙明-¹³C,d₃； 氟伏沙明马来酸盐-¹³C,d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42.  [Content Brief]

  [3]. Claassen, V., et al., Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br J Pharmacol, 1977. 60(4): p. 505-16.  [Content Brief]

  [4]. Escalona, R., et al., Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder. Depress Anxiety, 2002. 15(1): p. 29-33.  [Content Brief]