2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-PEG6-Val-Cit-PAB-OH

Fmoc-PEG6-Val-Cit-PAB-OH 是一种酶切 ADC 连接子，具有 Boc 保护的胺、亲水性 PEG 间隔物和 Val-Cit-PAB 二肽。PAB 上的苄醇可用于连接反应基团（例如 PNP），以与药物有效载荷结合。Fmoc 保护基团可用哌啶去除，露出一级胺，可用于偶联反应形成酰胺。Val-Cit-PAB 被细胞蛋白酶切割，以有效释放有效载荷到细胞。

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Fmoc-PEG6-Val-Cit-PAB-OH Chemical Structure

Fmoc-PEG6-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055024-57-0

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Fmoc-PEG6-Val-Cit-PAB-OH 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

Fmoc-PEG6-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

分子量

937.09

Formula

C48H68N6O13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Fmoc-PEG6-Val-Cit-PAB-OH 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Fmoc-PEG6-Val-Cit-PAB-OH2055024-57-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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