GAGE8 - G antigen 8 Gene

中文名称：G 抗原 8

种属: Homo sapiens

同用名: CT4.8; GAGE-8

关于 GAGE8

功能概要

该基因属于一个基因家族，在多种肿瘤中表达，但在除睾丸外的正常组织中不表达。家族成员的序列高度相关，但因分散的核苷酸取代而不同。也由几个其他家族成员编码的抗原肽 YRPRPPRRY 被自体溶细胞性 T 淋巴细胞识别。[RefSeq 提供，2008 年 7 月]

This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]