PDCD6 - programmed cell death 6 Gene

中文名称：程序性细胞死亡 6

种属: Homo sapiens

同用名: ALG2; ALG-2; PEF1B

关于 PDCD6

功能概要

该基因编码属于 penta-EF-hand 蛋白家族的钙结合蛋白。钙结合对于同二聚化和与其他蛋白质伙伴结合所需的构象变化很重要。该基因产物参与 T 细胞受体、Fas 和糖皮质激素诱导的程序性细胞死亡。然而，在缺乏该基因产物的小鼠中，细胞凋亡未被阻断，表明该基因产物在功能上是多余的。已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因也位于 5 号染色体的短臂上。[RefSeq 提供，2012 年 5 月]

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, Apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]