1. Gene
  2. TRIM28 - tripartite motif containing 28 Gene

TRIM28 - tripartite motif containing 28 Gene

中文名称:含三方基序 28

种属: Homo sapiens

同用名: KAP1; TF1B; RNF96; TIF1B; PPP1R157; TIF1beta

基因 ID: 10155 | 基因类型: protein coding

关于 TRIM28

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,544,064-58,550,715 (from NCBI)

This gene has 15 transcripts (splice variants), 143 orthologues, 80 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 89.1), testis (RPKM 80.5) and 25 other tissues.


由该基因编码的蛋白质通过与许多转录因子中发现的 Kruppel 相关框抑制域相互作用来介导转录控制。该蛋白质定位于细胞核,被认为与特定的染色质区域相关。该蛋白质是三联基序家族的成员。这个三联基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2,以及一个卷曲螺旋区域。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM28 基因产物(1)

mRNA Protein Name
NM_005762.3 NP_005753.1 transcription intermediary factor 1-beta

TRIM28 蛋白结构


zf-RING_5: zinc-RING finger domain (64 - 122)


zf-B_box: B-box zinc finger (150 - 194)


zf-B_box: B-box zinc finger (207 - 243)


PHD: PHD-finger (627 - 670)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
蛋白主名 其他名称

transcription intermediary factor 1-beta

E3 SUMO-protein ligase TRIM28


疾病名称 别名
Wilms Tumor 1


Wilms Tumor


Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Wilms Tumor 5

Wilms Tumor


Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia


Wilms' Tumor

Wilms Tumor, Susceptibility To


Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor


Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1


Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I


Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria


Hyperoxaluria, Primary


Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I

Hereditary Wilms' Tumor

Hereditary Wilms Tumor

Hereditary Wilms Tumour

Hereditary Wilms' Tumour


Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon


Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Burkitt Lymphoma

Burkitt'S Lymphoma


Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal


Chromosome 6-Associated Transient Diabetes Mellitus


Diabetes Mellitus, 6q24-Related Transient Neonatal


Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]

Autism Spectrum Disorder


Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder


Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified


Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome


疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Rattus norvegicus TRIM28 RGD RGD:620289
Macaca mulatta TRIM28 VGNC VGNC:79033
Bos taurus TRIM28 VGNC VGNC:36324
Felis catus TRIM28 VGNC VGNC:82332
Mus musculus TRIM28 MGD MGI:109274
Canis familiaris TRIM28 VGNC VGNC:47811