2. Gene
  3. TRIB1 - tribbles pseudokinase 1 Gene

TRIB1 - tribbles pseudokinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tribbles 假激酶 1

种属: Homo sapiens

同用名: C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1

基因 ID: 10221 | 基因类型: protein coding

关于 TRIB1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:125,430,358-125,438,403 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues.

功能概要

启用丝裂原活化蛋白激酶激酶结合活性和蛋白激酶抑制剂活性。涉及几个进程，包括 JNK 级联；脂多糖介导的信号通路的负调控；和蛋白激酶活性的调节。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIB1 基因产物(2)

mRNA Protein Name
NM_001282985.2 NP_001269914.1 tribbles homolog 1 isoform 2
NM_025195.4 NP_079471.1 tribbles homolog 1 isoform 1

TRIB1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (136 - 338)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
蛋白主名 其他名称

tribbles homolog 1

G-protein-coupled receptor induced protein

关联疾病

疾病名称 别名
Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia

Familial Hypobetalipoproteinemia 1

Familial Hypobetalipoproteinemia

FHBL1

Hypobetalipoproteinemia, Familial

Fhbl

Acanthocytosis With Hypobetalipoproteinemia

Hypobetalipoproteinemias

Hypobetalipoproteinemia, Normotriglyceridemic

Hypo-Beta-Lipoproteinemia

Hypobetalipoprotéinemia, Familial

Normotriglyceridemic Hypobetalipoproteinemia

Hypobetalipoproteinemia, Familial, Type 1
Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V

Hyperchylomicronemia, Late-Onset

Familial Type 5 Hyperlipoproteinemia

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

Hyperlipidemia, Type V

Hyperlipemia, Mixed

Hyperlipemia, Combined Fat And Carbohydrate-Induced

Familial Hyperlipoproteinemia Type V

Fredrickson Type V Lipaemia

Hyperlipoproteinemia Type 5

Hyperchylomicronemia Late Onset

Hyperlipemia Combined Fat And Carbohydrate-Induced

Hyperlipemia Mixed

Hyperlipidemia Type V

Mixed Hyperlipemia

Type V Hyperlipoproteinemia

Hyperlipoproteinemia 5

HLPP5

Hyperlipidemia, Familial Combined

Mixed Hyperlipidemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15015 TRIB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-123494 BRD0418 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRIB1 MGD MGI:2443397
Rattus norvegicus TRIB1 RGD RGD:621596
Bos taurus TRIB1 VGNC VGNC:36308
Macaca mulatta TRIB1 VGNC VGNC:79056
Felis catus TRIB1 VGNC VGNC:66527
Canis familiaris TRIB1 VGNC VGNC:55007
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