1. Gene
  2. MRPS31 - mitochondrial ribosomal protein S31 Gene

MRPS31 - mitochondrial ribosomal protein S31 Gene

中文名称:线粒体核糖体蛋白 S31

种属: Homo sapiens

同用名: S31mt; IMOGN38; MRP-S31

基因 ID: 10240 | 基因类型: protein coding

关于 MRPS31

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:40,729,128-40,771,190 (from NCBI)

This gene has 4 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 11.9), testis (RPKM 11.7) and 25 other tissues.


哺乳动物线粒体核糖体蛋白由核基因编码,有助于线粒体内的蛋白质合成。线粒体核糖体 (线粒体核糖体) 由一个小的 28S 亚基和一个大的 39S 亚基组成。与原核核糖体相比,它们估计有 75% 的蛋白质与 rRNA 组成,而原核核糖体的比例是相反的。哺乳动物 线粒体核糖体 和原核核糖体之间的另一个区别是后者包含 5S rRNA。在不同的物种中,构成核糖体的蛋白质在序列上有很大差异,有时在生化特性上也有很大差异,这使得序列同源性难以识别。哺乳动物 mitoribosome 的 28S 亚基可能在翻译起始中起着至关重要的特征作用。该基因编码的 28S 亚基蛋白也与 1 型糖尿病有关;然而,其与本病病因学的关系仍有待阐明。在 3 号和 13 号染色体上发现了与该基因相对应的假基因。[RefSeq 提供,2008 年 7 月]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]

MRPS31 基因产物(1)

mRNA Protein Name
NM_005830.4 NP_005821.2 28S ribosomal protein S31, mitochondrial

MRPS31 蛋白结构


MRP-S31: Mitochondrial 28S ribosomal protein S31 (96 - 389)

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  • 395 a.a.
蛋白主名 其他名称

28S ribosomal protein S31, mitochondrial

imogen 38


种属 基因名 来源 基因 ID
Felis catus MRPS31 VGNC VGNC:63623
Bos taurus MRPS31 VGNC VGNC:31670
Mus musculus MRPS31 MGD MGI:1913153
Canis familiaris MRPS31 VGNC VGNC:43421
Rattus norvegicus MRPS31 RGD RGD:1307668
Macaca mulatta MRPS31 VGNC VGNC:74777