MIR6859-1 - microRNA 6859-1 Gene

中文名称：微小 RNA 6859-1

种属: Homo sapiens

同用名: hsa-mir-6859-1

关于 MIR6859-1

功能概要

微小 RNA (miRNA) 是短的 (20-24 nt) 非编码 RNA，通过影响 mRNA 的稳定性和翻译，参与多细胞生物中基因表达的转录后调控。 miRNA 由 RNA 聚合酶 II 转录，作为加帽和聚腺苷酸化初级转录物 (pri-miRNA) 的一部分，可以是蛋白质编码或非编码的。初级转录物被 Drosha 核糖核酸酶 III 酶切产生大约 70 nt 的茎环前体 miRNA (pre-miRNA) ，它被细胞质 Dicer 核糖核酸酶进一步切割以产生成熟的 miRNA 和反义 miRNA 星 (miRNA * ) 产品。成熟的 miRNA 被整合到 RNA 诱导的沉默复合体 (RISC) 中，它通过与 miRNA 的不完美碱基配对识别靶 mRNA，最常见的结果是靶 mRNA 的翻译抑制或不稳定。 RefSeq 代表预测的 MicroRNA 茎环。[RefSeq 提供，2009 年 9 月]

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III Enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]