CENPA - centromere protein A Gene

中文名称：着丝粒蛋白 A

种属: Homo sapiens

同用名: CenH3; CENP-A

基因 ID: 1058 | 基因类型: protein coding

关于 CENPA

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,786,056-26,794,589 (from NCBI)

This gene has 6 transcripts (splice variants), 213 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.5) and 14 other tissues.

功能概要

着丝粒是分化的染色体结构域，它指定染色体的有丝分裂行为。该基因编码一种着丝粒蛋白，该蛋白包含靶向着丝粒所需的组蛋白 H3 相关组蛋白折叠结构域。着丝粒蛋白 A 被认为是修饰的核小体或核小体样结构的一个组成部分，其中它取代了核小体颗粒 (H3-H4) 2 四聚体核心中常规组蛋白 H3 的 1 个或两个拷贝。该蛋白是一种不依赖于复制的组蛋白，是组蛋白 H3 家族的一员。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 11 月]

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

CENPA 基因产物(2)

mRNA	Protein	Name
NM_001042426.2	NP_001035891.1	histone H3-like centromeric protein A isoform b
NM_001809.4	NP_001800.1	histone H3-like centromeric protein A isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19410544	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CENP-A containing chromatin assembly	IDA IDA: 通过直接分析推断	11682612	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: 通过突变表型推断	19468067	GOA
involved in kinetochore assembly	IDA IDA: 通过直接分析推断	11682612	GOA
involved in mitotic cytokinesis	IMP IMP: 通过突变表型推断	27499292	GOA
involved in protein localization to chromosome, centromeric region	IDA IDA: 通过直接分析推断	11682612	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CENP-A containing nucleosome	IDA IDA: 通过直接分析推断	18195732	GOA
part of CENP-A containing nucleosome	IPI IPI: 通过物理相互作用推断	21743476	GOA
located in chromosome, centromeric region	IDA IDA: 通过直接分析推断	11084331	GOA
located in condensed chromosome, centromeric region	IDA IDA: 通过直接分析推断	11682612	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	27499292	GOA
located in nucleus	IDA IDA: 通过直接分析推断	27499292	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CENPA 蛋白结构

Histone

0
100
140 a.a.

蛋白主名

其他名称

histone H3-like centromeric protein A

centromere autoantigen A

CENPA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CENPA	P49450	H4C16	Homo sapiens	P62805	X-Ray Diffraction	21478274
种属内	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	21478274
种属内	CENPA	P49450	H4C16	Homo sapiens	P62805	TAP	19410544
种属内	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	26167883
种属内	CENPA	P49450	MCM2	Homo sapiens	P49736	GMS	26167883
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	TAP	19410544
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	X-Ray Diffraction	21478274
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	GMS	21478274
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	35271311
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Density Sedimentation	19410544
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Bait CoIP	19410545
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	19410545
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Pull Down	19410545
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	26496610
种属内	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	33961781
种属内	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
种属内	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
种属内	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

CENPA 抗体

目录号	产品名	应用	反应物种
HY-P81580	CENPA Antibody (YA1325)	WB, ICC/IF	Human
HY-P81908	CENPA Antibody (YA1653)	WB	Human
HY-P86162	CENPA Antibody (YA5854)	WB, ICC/IF, IP, ELISA	Human

关联疾病

疾病名称

别名

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Crest Syndrome

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Esophageal Leukoplakia

Leukoplakia Of Esophagus

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Telangiectasis

Telangiectasia

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02473	CENPA Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19662	Cenpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26155	Cenpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CENPA	RGD	RGD:1563607
Mus musculus	CENPA	MGD	MGI:88375
Felis catus	CENPA	VGNC	VGNC:60752
Macaca mulatta	CENPA	VGNC	VGNC:71005
Canis familiaris	CENPA	VGNC	VGNC:39101

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CENPA - centromere protein A Gene

关于 CENPA

功能概要

CENPA 基因产物(2)

CENPA 蛋白结构

CENPA 蛋白互作信息

CENPA 抗体

关联疾病

直系同源

热门区域

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CENPA - centromere protein A Gene

关于 CENPA

功能概要

CENPA 基因产物(2)

CENPA 蛋白结构

CENPA 蛋白互作信息

CENPA 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z