1. Gene
  2. TRIM16 - tripartite motif containing 16 Gene

TRIM16 - tripartite motif containing 16 Gene

中文名称:含三方基序 16

种属: Homo sapiens

同用名: EBBP

基因 ID: 10626 | 基因类型: protein coding

关于 TRIM16

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,627,966-15,684,311 (from NCBI)

This gene has 26 transcripts (splice variants), 225 orthologues and 80 paralogues. Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues.

功能概要

由该基因编码的蛋白质是一个三联基序 (TRIM) 家族成员,包含两个 B 盒结构域和一个卷曲螺旋区域,这是 B 盒锌指蛋白家族的特征。虽然它缺少在其他 TRIM 蛋白中发现的 RING 结构域,但编码的蛋白可以与其他 TRIM 蛋白同二聚化或异二聚化,并具有 E3 泛素连接酶活性。该基因也是一种肿瘤抑制基因,并参与分泌性自噬。[RefSeq 提供,2017 年 1 月]

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory Autophagy. [provided by RefSeq, Jan 2017]

TRIM16 基因产物(8)

mRNA Protein Name
NM_001348119.1 NP_001335048.1 tripartite motif-containing protein 16 isoform a
NM_001348120.1 NP_001335049.1 tripartite motif-containing protein 16 isoform a
NM_001348121.1 NP_001335050.1 tripartite motif-containing protein 16 isoform b
NM_001348122.1 NP_001335051.1 tripartite motif-containing protein 16 isoform b
NM_001348124.1 NP_001335053.1 tripartite motif-containing protein 16 isoform c
NM_001348125.1 NP_001335054.1 tripartite motif-containing protein 16 isoform c
NM_001348126.1 NP_001335055.1 tripartite motif-containing protein 16 isoform d
NM_006470.4 NP_006461.3 tripartite motif-containing protein 16 isoform a

TRIM16 蛋白结构

zf-B_box

zf-B_box: B-box zinc finger (129 - 165)

PRY

PRY: SPRY-associated domain (375 - 423)

SPRY

SPRY: SPRY domain (427 - 549)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 16

E3 ubiquitin-protein ligase TRIM16

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM16 RGD RGD:1309749
Bos taurus TRIM16 VGNC VGNC:107280
Mus musculus TRIM16 MGD MGI:2137356
Others TRIM16 NCBI