2. Gene
  3. SLC22A7 - solute carrier family 22 member 7 Gene

SLC22A7 - solute carrier family 22 member 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 7

种属: Homo sapiens

同用名: NLT; OAT2; hOAT11

基因 ID: 10864 | 基因类型: protein coding

关于 SLC22A7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,295,714-43,305,538 (from NCBI)

This gene has 9 transcripts (splice variants), 414 orthologues and 22 paralogues. Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9).

功能概要

该基因编码的蛋白质参与了有机阴离子的非钠依赖性转运和排泄，其中一些具有潜在毒性。编码的蛋白质是一种完整的膜蛋白，似乎位于肾脏的基底外侧膜。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SLC22A7 基因产物(2)

mRNA Protein Name
NM_006672.3 NP_006663.2 solute carrier family 22 member 7 isoform a
NM_153320.2 NP_696961.2 solute carrier family 22 member 7 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: 通过直接分析推断
11327718 GOA
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
11327718 GOA
enables organic anion transmembrane transporter activity IMP
IMP: 通过突变表型推断
21446918 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: 通过直接分析推断
11907186 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15846844 GOA
enables transmembrane transporter activity IDA
IDA: 通过直接分析推断
18216183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alpha-ketoglutarate transport IDA
IDA: 通过直接分析推断
11327718 GOA
involved in prostaglandin transport IDA
IDA: 通过直接分析推断
11907186 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
25904762 GOA
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
25904762 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18216183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A7 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (143 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 548 a.a.
蛋白主名 其他名称

solute carrier family 22 member 7

hOAT2

关联疾病

疾病名称 别名
Gout

Gouty Arthritis

Articular Gout

Gouty Arthropathy

Arthritis, Gouty

Arthritis Gouty

Idiopathic Gout

Idiopathic Gout, Unspecified Site

Gouty Bursitis

Uratic Arthritis

Gout Nos

Gouty

Gouty Diathesis
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency

Deficiency Of Glucose-6-Phosphate Dehydrogenase

Glucose 6 Phosphate Dehydrogenase Deficiency

Deficiency Of G-6pd

G6pdd
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13079 SLC22A7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22036 Slc22a7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC22A7 RGD RGD:621699
Canis familiaris SLC22A7 VGNC VGNC:57234
Mus musculus SLC22A7 MGD MGI:1859559
Bos taurus SLC22A7 VGNC VGNC:34731
Felis catus SLC22A7 VGNC VGNC:65246
Macaca mulatta SLC22A7 VGNC VGNC:83467
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