STIP1 - stress induced phosphoprotein 1 Gene

中文名称：应激诱导磷蛋白 1

种属: Homo sapiens

同用名: HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521

关于 STIP1

功能概要

STIP1 是一种衔接蛋白，可协调 HSP70 (参见 HSPA1A；MIM 140550) 和 HSP90 (参见 HSP90AA1；MIM 140571) 在蛋白质折叠中的功能。它被认为通过结合 HSP90 和底物结合的 HSP70 来帮助蛋白质从 HSP70 转移到 HSP90。 STIP1 还刺激 HSP70 的 ATP 酶活性并抑制 HSP90 的 ATP 酶活性，表明它调节这些伴侣的构象和 ATP 酶循环 (Song 和 Masison，2005 [PubMed 16100115]) 。[OMIM 提供，2009 年 7 月]

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]