1. Gene
  2. DIDO1 - death inducer-obliterator 1 Gene

DIDO1 - death inducer-obliterator 1 Gene

中文名称:死亡诱导-抹杀者 1

种属: Homo sapiens

同用名: BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8

基因 ID: 11083 | 基因类型: protein coding

关于 DIDO1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,877,743-62,937,904 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.7), spleen (RPKM 4.7) and 25 other tissues.


细胞凋亡是细胞死亡的一种主要形式,是消除不需要的细胞的有效机制,对于后生动物的发育和稳态至关重要。在小鼠中,死亡诱导剂-闭塞器-1 基因被凋亡信号上调,并编码一种细胞质蛋白,该蛋白在凋亡信号激活时易位至细胞核。当过度表达时,小鼠蛋白在体外生长的细胞系中诱导细胞凋亡。该基因与小鼠基因相似,因此被认为与细胞凋亡有关。已发现该基因的可变剪接转录本,编码多种亚型。[RefSeq 提供,2008 年 7 月]

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan Animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced Apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in Apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

DIDO1 基因产物(6)

mRNA Protein Name
NM_001193369.2 NP_001180298.1 death-inducer obliterator 1 isoform c
NM_001193370.2 NP_001180299.1 death-inducer obliterator 1 isoform b
NM_022105.5 NP_071388.2 death-inducer obliterator 1 isoform a
NM_033081.3 NP_149072.2 death-inducer obliterator 1 isoform c
NM_080796.4 NP_542986.1 death-inducer obliterator 1 isoform a
NM_080797.4 NP_542987.2 death-inducer obliterator 1 isoform b

DIDO1 蛋白结构


PHD: PHD-finger (270 - 320)


TFIIS_M: Transcription factor S-II (TFIIS), central domain (667 - 777)


SPOC: SPOC domain (1057 - 1163)

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  • 2240 a.a.
蛋白主名 其他名称

death-inducer obliterator 1

death-associated transcription factor 1


种属 基因名 来源 基因 ID
Mus musculus DIDO1 MGD MGI:1344352
Macaca mulatta DIDO1 VGNC VGNC:71736
Bos taurus DIDO1 VGNC VGNC:28064
Felis catus DIDO1 VGNC VGNC:80083
Rattus norvegicus DIDO1 RGD RGD:1311173
Canis familiaris DIDO1 VGNC VGNC:54296