2. Gene
  3. KAT7 - lysine acetyltransferase 7 Gene

KAT7 - lysine acetyltransferase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：赖氨酸乙酰转移酶 7

种属: Homo sapiens

同用名: HBO1; HBOA; MYST2; ZC2HC7

基因 ID: 11143 | 基因类型: protein coding

关于 KAT7

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,788,681-49,835,026 (from NCBI)

This gene has 19 transcripts (splice variants), 267 orthologues, 9 paralogues and is associated with 64 phenotypes. Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues.

功能概要

该基因编码的蛋白质是多聚体 HBO1 复合物的一部分，它具有组蛋白 H4 特异性乙酰转移酶活性。此活动是功能性复制起点所必需的，并且参与某些基因的转录激活。在这两种情况下，组蛋白 H4 的乙酰化有助于展开染色质，从而可以访问、复制或转录 DNA。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

KAT7 基因产物(6)

mRNA Protein Name
NM_001199155.2 NP_001186084.1 histone acetyltransferase KAT7 isoform 2
NM_001199156.2 NP_001186085.1 histone acetyltransferase KAT7 isoform 3
NM_001199157.2 NP_001186086.1 histone acetyltransferase KAT7 isoform 4
NM_001199158.2 NP_001186087.1 histone acetyltransferase KAT7 isoform 5
NM_001346706.2 NP_001333635.1 histone acetyltransferase KAT7 isoform 6
NM_007067.5 NP_008998.1 histone acetyltransferase KAT7 isoform 1

KAT7 蛋白结构

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (183 - 212)

MOZ_SAS

MOZ_SAS: MOZ/SAS family (390 - 574)

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  • 611 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT7

K(lysine) acetyltransferase 7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134901 WM-3835 99.63% 否
HY-102058 WM-1119 Inhibitor 99.83% 否
HY-RS07083 KAT7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KAT7 MGD MGI:2182799
Felis catus KAT7 VGNC VGNC:63026
Macaca mulatta KAT7 VGNC VGNC:99160
Bos taurus KAT7 VGNC VGNC:30403
Canis familiaris KAT7 VGNC VGNC:42214
Rattus norvegicus KAT7 RGD RGD:727966
Others KAT7 NCBI
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