1. Gene
  2. PADI2 - peptidyl arginine deiminase 2 Gene

PADI2 - peptidyl arginine deiminase 2 Gene

中文名称:肽基精氨酸脱亚胺酶 2

种属: Homo sapiens

同用名: PAD2; PDI2; PAD-H19

基因 ID: 11240 | 基因类型: protein coding

关于 PADI2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,066,761-17,119,451 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 4 paralogues. Biased expression in colon (RPKM 47.2), brain (RPKM 33.8) and 6 other tissues.


该基因编码肽基精氨酸脱亚胺酶家族的成员,该酶通过在钙离子存在下将精氨酸残基转化为瓜氨酸来催化蛋白质的翻译后脱亚胺。该家族成员具有不同的底物特异性和组织特异性表达模式。 II 型酶是表达最广泛的家族成员。这种酶的已知底物包括中枢神经系统中的髓鞘碱性蛋白和骨骼肌和巨噬细胞中的波形蛋白。这种酶被认为在神经退行性人类疾病 (包括阿尔茨海默病和多发性硬化症) 的发病和进展中发挥作用,并且它还与青光眼的发病机制有关。该基因与其他四个旁系同源基因存在于一个簇中。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II Enzyme is the most widely expressed family member. Known substrates for this Enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This Enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI2 基因产物(1)

mRNA Protein Name
NM_007365.3 NP_031391.2 protein-arginine deiminase type-2

PADI2 蛋白结构


PAD_N: Protein-arginine deiminase (PAD) N-terminal domain (1 - 114)


PAD_M: Protein-arginine deiminase (PAD) middle domain (116 - 274)


PAD: Protein-arginine deiminase (PAD) (280 - 665)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
蛋白主名 其他名称

protein-arginine deiminase type-2

peptidyl arginine deiminase, type II

重组 PADI2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78738 PADI2 Protein, Human (HEK293, His) Q9Y2J8-1 (M1-P665) ≥95%
HY-P700602 PADI2 Protein, Human (HEK293, N-His, C-Myc) Q9Y2J8 (M1-P665) ≥95%


疾病名称 别名
Multiple Sclerosis


Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Felty Syndrome

Felty'S Syndrome

Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia

Familial Felty'S Syndrome

Rheumatoid Arthritis, Splenomegaly And Neutropenia

Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome

Feltys Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Macaca mulatta PADI2 VGNC VGNC:75644
Rattus norvegicus PADI2 RGD RGD:3288
Canis familiaris PADI2 VGNC VGNC:44235
Mus musculus PADI2 MGD MGI:1338892
Felis catus PADI2 VGNC VGNC:64022
Bos taurus PADI2 VGNC VGNC:32546