1. Gene
  2. PTGDR2 - prostaglandin D2 receptor 2 Gene

PTGDR2 - prostaglandin D2 receptor 2 Gene

中文名称:前列腺素 D2 受体 2

种属: Homo sapiens

同用名: DP2; DL1R; CD294; CRTH2; GPR44

基因 ID: 11251 | 基因类型: protein coding


Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,850,933-60,855,950 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 17 paralogues. Broad expression in stomach (RPKM 4.7), colon (RPKM 3.6) and 21 other tissues.


该基因编码一种 G 蛋白偶联受体,该受体优先在 CD4+ 效应 T 辅助细胞 2 (Th2) 细胞中表达。这种蛋白质是一种前列腺素 D2 受体,可介导过敏性炎症期间产生的嗜酸性粒细胞、嗜碱性粒细胞和 Th2 淋巴细胞的促炎趋化作用。该基因 3' UTR 的单核苷酸多态性与哮喘易感性有关。[RefSeq 提供,2011 年 3 月]

This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

PTGDR2 基因产物(1)

mRNA Protein Name
NM_004778.3 NP_004769.2 prostaglandin D2 receptor 2

PTGDR2 蛋白结构


7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 304)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
蛋白主名 其他名称

prostaglandin D2 receptor 2

G-protein coupled receptor 44

chemoattractant receptor homologous molecule expressed on T helper type 2 cells

chemoattractant receptor-homologous molecule expressed on TH2 cells

putative G-protein coupled receptor 44


疾病名称 别名
Contact Blepharoconjunctivitis
Dermatitis, Atopic, 5


Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5

Nasal Cavity Disease

Disorder Of Nasal Cavity


Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Apricot Allergy

Prunus Armeniaca Fruit Allergy

Chronic Rhinitis

Rhinitis - Chronic

Chronic Rhinitis Nos


Rhinitis Nos

T2-High Asthma

Type 2 High Endotype

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1


Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic


Besnier Prurigo

Chronic Asthma
Diclofenac Allergy

Voltaren Allergy

T2-Low Asthma

Type 2 Low Endotype

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Pollen Allergy

Hay Fever

Spherocytosis, Type 2

Hereditary Spherocytosis Type 2


Spherocytosis, Hereditary, 2


Hereditary Spherocytosis 2

Spherocytosis 2

Spherocytosis, Type 2, Autosomal Dominant

Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax



Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis


Esophagitis, Eosinophilic


Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute



Common Colds

Acute Infective Rhinitis



Head Cold

Infective Nasopharyngitis


Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos


Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Fruit Allergy

Allergy To Fruit


Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva


Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Bos taurus PTGDR2 VGNC VGNC:33500
Macaca mulatta PTGDR2 VGNC VGNC:76358
Rattus norvegicus PTGDR2 RGD RGD:1311986
Felis catus PTGDR2 VGNC VGNC:104317
Canis familiaris PTGDR2 VGNC VGNC:45141
Mus musculus PTGDR2 MGD MGI:1330275