2. Gene
  3. XPOT - exportin for tRNA Gene

XPOT - exportin for tRNA Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tRNA 输出

种属: Homo sapiens

同用名: XPO3

基因 ID: 11260 | 基因类型: protein coding

关于 XPOT

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:64,404,392-64,451,125 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues.

功能概要

该基因编码属于 RAN-GTPase 输出蛋白家族的一种蛋白质，该家族介导 tRNA 从细胞核输出到细胞质。一旦 exportin 结合 tRNA 和 GTP 结合的 RAN，就会发生 tRNA 向细胞质的易位。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

XPOT 基因产物(1)

mRNA Protein Name
NM_007235.6 NP_009166.2 exportin-T

XPOT 蛋白结构

Xpo1

Xpo1: Exportin 1-like protein (99 - 247)

  • 0
  • 200
  • 400
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  • 800
  • 962 a.a.
蛋白主名 其他名称

exportin-T

exportin(tRNA)

关联疾病

疾病名称 别名
Severe Congenital Neutropenia 6

Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency

Scn6
Glaucoma, Normal Tension

Low Tension Glaucoma

Glaucoma, Normal Tension, Susceptibility To

Normal Tension Glaucoma

Ntg

Glaucoma, Normal Pressure

NPG

Glaucoma, Normal Pressure, Susceptibility To

Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158820 Cosdosiran / 否
HY-158820A Cosdosiran sodium / 否
HY-E70364 IgdE protease / 否
HY-RS15894 XPOT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus XPOT VGNC VGNC:67116
Rattus norvegicus XPOT RGD RGD:1305562
Canis familiaris XPOT VGNC VGNC:48465
Mus musculus XPOT MGD MGI:1920442
Macaca mulatta XPOT VGNC VGNC:100123
Bos taurus XPOT VGNC VGNC:37002
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